21. CD 19 is marker for
a. T-cells
b. B-cells
c. Macrophage
d. Natural Killer cells
22. The following peptide with sequence FARPCSRPGF was digested with trypsin, chymotrypsin and carboxypeptidase A. The number of peptide fragments produced
a. 0
b. 2
c. 3
d. 4
23. On treating pre-B cell with phorbol ester, which of the following is NOT a outcome
a. It phosphorylates NF-kB
d. It activates protein kinase C
c. It activates NF-kB for translocation into nuclues
d. It helps in removal of inhibitor from NF-kB
24. The nuclear export signal on cytosolic proteins helps them to be exported from the nucleus after
a. At the time of replication
b. before DNA replication
c. Mitosis
d. Mitosis and meiosis
25. ABC transporter are
a. Found only in eukaryotes
b. Non-specific for molecule to be transported
c. Have both transmembrane domain and nucleotide-binding domain
d. Are P-glycoproteins
26. Which nitrogen of adenine gets protonated if pH of surrounding is lowered from 7 to 3?
a. N3
b. N1
c. N7
d. N9
27. B-DNA is stabilized by the
a. Hydrogen bonding
b. Ionic interaction
c. Vander wall Interactions
d. Covalent Linkage
28. The major biosynthetic pathways for terpenes synthesis are
a. Malonic acid and MEP pathway
b. Mevalonic acid and MEP pathway
c. Shikimik acid and Mevalonic acid pathway
d. Malonic acid and Mevalonic acid pathway
29. Match the following
A. Azolla 1. Nostoc
B. Casurina 2. Bradyrhyzobium
C. Guneria 3. Anabena
D. Soyabean 4. Frankia
a. A-3, B-2, C-3, D-1
b. A-4, B-3, C-2, D-1
c. A-3, B-1, C-4, D-2
d. A-1, B-2, C-3, D-4
30. Regulatory sequences for rRNA genes resides at
a. Spacer region between genes
b. Multiple sites at non-transcribe spacer region
c. 5’ flanking region of individual rRNA gene cluster
d. Within the coding transcribed region of gene
31. Certain eukaryotic mRNA has IRES sequence because
a. Inhibit translation
b. helps in mRNA synthesis during stress survival
c. Neutralizes effect of siRNA
d. enhances transcription
32. Mycobacterium tuberculosis infects mainly
a. Macrophages
b. Alevelor cells
c. Epithelial cells
d. TH cells
33. The false statement about siRNA is
a. 21-23 bp long with 2-3 nt overhang at 5’ end
b. Generally do not act at transcriptional level
c. It is induced by viruses
d. It processed by RISC complex
34. Integrin binds to _____ ECM molecule?
a. Collagen
b. Laminin
c. vitronectin
d. Fibronectin
35. The major stimulus for bacterial spore formation
a. Heat Stress
b. pH
c. Cold stess
d. Nutrient limitation
36. Not correct match?
a. erbA-Thryoid receptor
b. fos-PDGF receptor
c. erbB - EGF receptor
d. ras-GTPase activity
37. Phosphatidyl Serine is present on _______________ side of bacterial membrane
a. Outer leaflet of plasma membrane
b. Inner leaflet of plasma membrane
c. Both leaflets of plasma membrane
d. Generally present on inner leaflet but may be outside under certain conditions
38. The protein, Ced-9 regulates apoptosis in C. elegans, which controls the Ced-4 protein activity. Which of the following will lead to apoptosis?
a. Over expression of Ced-9
b. Loss of function of Ced-4
c. Loss of function of Ced-9
d. Loss of function both of Ced-9 and Ced-4
39. Meaning of fermentation in biochemistry (C) and Microbial technology (T) are used in different sense. Which of the following is true?
a. Both are same
b. All T is C but reverse is not true
c. All C is T but reverse is not true
d. Both are aerobic process
41. Origin of Knewkoop center and dorsal organizer is Xenopus levis is from
a. Ectoderm and endoderm
b. Ectoderm and mesoderm
c. Mesoderm and endoderm
d. Mesoderm only
42. The following protein(s) of PSII which binds to P680 and primary acceptor pheophytin are
a. p700
b. FeS complex
c. CP1 and CP2
d. D1 and D2 Proteins
43. Following is not true for Agrobacterium infection of plant?
a. Vir A and G binds to acetosyringone
b. Vir D1/2 is responsible for single stranded cut in T-DNA
c. Vir B forms bridge between bacterium and plant cell during infection
d. Vir F and VIF coats single stranded T-DNA during passage from bacterium to nucleus of plant cell
44. The following is not a mechanism for removing pollutant from soil using phytoremediation?
a. Phytodegradation
b. Phytoextraction
c. Phytomining
d. Chelating pollutant by secretion of chemicals by plants
45. Which of the following is suitable for cloning 140 kb eukaryotic DNA fragments for constructing genomic library?
a. Phage
b. Plasmid
c. BAC
d. YAC
46. The use of biotinylated antiobody in ELISA?
a. increase specificity but compromises sensitivity
b. decreases both specificity and sensitivity
c. increase sensitivity without compromising specificity
d. cannot be used after transfer of protein on nitrocellulose sheet
47. Secondary sewage treatment involves
a. Sedimentation of organic wastes
b. Killing of pathogens by chlorination and opsionization
c. Use of trickling filters
d. Filtration
48. Which of the following pair are responsible for site specific recombination?
a. DNA polymerase III and ligase
b. DNA polymerase I and ligase
c. DNA polymerase II and ligase
d. Restriction endonuclease and ligase
49. If we want to test toxic effect of drug on liver then which would be suitable choice?
a. Liver cell line
b. Intact liver
c. Kupffer cells
d. Mixture of kupffer cells and liver cells
50. If ‘r’ denotes correlation coefficient and ‘m’ denotes slope of regression, then changing both X and Y axis will
a. change ‘r’ only keeping ‘m’ constant
b. keeps both ‘r’ and ‘m’ constant
c. change ‘m’ only keeping ‘r’ constant
d. changes both ‘r’ and ‘m’
51. As the plants are adapted for many photoreceptors for different wavelengths, which is true?
a. phytochrome A perceives red light
b. phytochrome C perceives far red light
c. phytochrome and cryptochrome perceives blue light
d. phytochrome B predominantly perceives far red light
52. Pholem Loading in plants is characterized by
a. movement of triose phosphate from chloroplast to cytosol
b. movement of sugar from source to sink in sieve element
c. mass flow of phloem sap to different parts of plants
d. transport of sugar from photosynthetic bundle sheath cell to companion cell
53. During pregnancy, the correct reason for initiating maternal behavior in females?
a. high level of estrogen and progesterone in blood
b. changes in uterine lining
c. high prolactin level in blood
d. sight of male
54. Sympathetic system increase heart rate by regulating
a. L type Ca2+ channel.
b. Na+ channel
c. T type Ca2+ channel
d. Cl- channel
55. One person suffering diabetes takes regularly 1 ml of insulin at 9 AM. One day he took 1.5 ml of insulin at scheduled time considering that he will go to party at 11 AM. But that day, he missed breakfast but took sufficient lunch in party. Which of the following scenario would be most suitable?
a. he will be hyperglycemic before lunch
b. he will be hypoglycemic after lunch
c. he will be hypoglycemic before lunch
d. Blood glucose level will remain in control before and after lunch
56. A tRNA gene is mutated at anticodon region to recognize stop codon and allow translation beyond pre mature stop codon in mRNA transcribed from mutated protein coding gene, such that functional protein is produced. Such a phenomenon is termed as
a. Reverse mutation
b. Neutral mutation
c. Nonsense suppressive mutation
d. Point mutation
57. A change on one locus to another locus of the same gene results in mutation. The two copies of mutated same gene termed as
a. complementation group
b. linkage group
c. duplicate genes
d. allele
58. A male mouse always produces female puff on mating. The reason is
a. defect in spermatogenesis
b. All sperms germ cells have X chromosomes
c. Activation of lethal gene associated with Y chromosome
d. Activation of lethal gene associated with X-chromosome
59. Two plants species having cob length of 9 cm and 3 cm were crossed. Assume trait for cob length is polygenic and additive property, what would be the cob length of progenies?
a. 3 cm
b. 6 cm
c. 9 cm
d. 12 cm
60. How many gametes would be formed from genotype AaBBccDdEe?
a. 8
b. 16
c. 32
d. 64
61. The correct explanation for paraphyltetic group?
a. contains unrelated organisms
b. includes recent ancestors
c. includes all common ancestors
d. includes all representatives but ancestors are not included
62. Which of the following microorganism extensively utilized in organic farming?
a. Rhyzopus
b. Trichorderma viride
c. Mucor
d. Fusarium
63. NOT an adaptation to xerophytic conditions in plants?
a. Sunken stomata
b. Sparse stomata
c. Lenticular tissues
d. Sclerenchymatous tissues
64. If the milk is left open in vessel, at first, lactose is fermented by bacteria producing acid. Later there is proteolytic degradation activity which increases pH and finally left over fat is degraded by another type of bacteria. This is an example of
a. Competition
b. Microevolution
c. Ecological succession
d. Antagonism
65. Which amongst the following has the highest per molecule green house effect?
a. CO2
b. CH4
c. NOx
d. CFCs
66. According to Hardy-Weinberg equilibrium, the allele frequency of gene pool will not change when
a. There is microevolution
b. There is migration
c. There is genetic drift
d. There is no evolution
67. Consider the following events in history of life?
I. prokaryotic cell
II. eukaryotic cell
III. natural selection
IV. organic macromolecules
V. formation of replicating molecule
Which of the following is correct sequence?
a. d→e→I→c→II
b. IV→V→I→II→III
c. IV→V→III→I→II
d. V→III→I→II→IV
68. During inter sexual selection the development of certain traits is seen only in males only, due to
a. Males experience lesser energy expenditure through maintenance of weapons, such as horns and antlers, then do females.
b. Male reproductive success is limited by access to forage more than female reproductive success is by access to forage
c. Female has very high reproductive and breeding cost as well as investment in parental care
d. Female reproductive success is more limited by access to males than male reproductive success is access to females.
69. The best technique to identify the Mycoplasma infection in animal cell line?
a. ELISA
b. PCR
c. Southern Hybridization
d. Northern Hybridization
70. In drug delivery, the major disadvantage of using liposome is
a. It is phagocytosised by neutrophils
b. It intercalates in plasma membrane
c. It is unstable and has small shelf life
d. Drug entrapment efficiency is very low
a. T-cells
b. B-cells
c. Macrophage
d. Natural Killer cells
22. The following peptide with sequence FARPCSRPGF was digested with trypsin, chymotrypsin and carboxypeptidase A. The number of peptide fragments produced
a. 0
b. 2
c. 3
d. 4
23. On treating pre-B cell with phorbol ester, which of the following is NOT a outcome
a. It phosphorylates NF-kB
d. It activates protein kinase C
c. It activates NF-kB for translocation into nuclues
d. It helps in removal of inhibitor from NF-kB
24. The nuclear export signal on cytosolic proteins helps them to be exported from the nucleus after
a. At the time of replication
b. before DNA replication
c. Mitosis
d. Mitosis and meiosis
25. ABC transporter are
a. Found only in eukaryotes
b. Non-specific for molecule to be transported
c. Have both transmembrane domain and nucleotide-binding domain
d. Are P-glycoproteins
26. Which nitrogen of adenine gets protonated if pH of surrounding is lowered from 7 to 3?
a. N3
b. N1
c. N7
d. N9
27. B-DNA is stabilized by the
a. Hydrogen bonding
b. Ionic interaction
c. Vander wall Interactions
d. Covalent Linkage
28. The major biosynthetic pathways for terpenes synthesis are
a. Malonic acid and MEP pathway
b. Mevalonic acid and MEP pathway
c. Shikimik acid and Mevalonic acid pathway
d. Malonic acid and Mevalonic acid pathway
29. Match the following
A. Azolla 1. Nostoc
B. Casurina 2. Bradyrhyzobium
C. Guneria 3. Anabena
D. Soyabean 4. Frankia
a. A-3, B-2, C-3, D-1
b. A-4, B-3, C-2, D-1
c. A-3, B-1, C-4, D-2
d. A-1, B-2, C-3, D-4
30. Regulatory sequences for rRNA genes resides at
a. Spacer region between genes
b. Multiple sites at non-transcribe spacer region
c. 5’ flanking region of individual rRNA gene cluster
d. Within the coding transcribed region of gene
31. Certain eukaryotic mRNA has IRES sequence because
a. Inhibit translation
b. helps in mRNA synthesis during stress survival
c. Neutralizes effect of siRNA
d. enhances transcription
32. Mycobacterium tuberculosis infects mainly
a. Macrophages
b. Alevelor cells
c. Epithelial cells
d. TH cells
33. The false statement about siRNA is
a. 21-23 bp long with 2-3 nt overhang at 5’ end
b. Generally do not act at transcriptional level
c. It is induced by viruses
d. It processed by RISC complex
34. Integrin binds to _____ ECM molecule?
a. Collagen
b. Laminin
c. vitronectin
d. Fibronectin
35. The major stimulus for bacterial spore formation
a. Heat Stress
b. pH
c. Cold stess
d. Nutrient limitation
36. Not correct match?
a. erbA-Thryoid receptor
b. fos-PDGF receptor
c. erbB - EGF receptor
d. ras-GTPase activity
37. Phosphatidyl Serine is present on _______________ side of bacterial membrane
a. Outer leaflet of plasma membrane
b. Inner leaflet of plasma membrane
c. Both leaflets of plasma membrane
d. Generally present on inner leaflet but may be outside under certain conditions
38. The protein, Ced-9 regulates apoptosis in C. elegans, which controls the Ced-4 protein activity. Which of the following will lead to apoptosis?
a. Over expression of Ced-9
b. Loss of function of Ced-4
c. Loss of function of Ced-9
d. Loss of function both of Ced-9 and Ced-4
39. Meaning of fermentation in biochemistry (C) and Microbial technology (T) are used in different sense. Which of the following is true?
a. Both are same
b. All T is C but reverse is not true
c. All C is T but reverse is not true
d. Both are aerobic process
41. Origin of Knewkoop center and dorsal organizer is Xenopus levis is from
a. Ectoderm and endoderm
b. Ectoderm and mesoderm
c. Mesoderm and endoderm
d. Mesoderm only
42. The following protein(s) of PSII which binds to P680 and primary acceptor pheophytin are
a. p700
b. FeS complex
c. CP1 and CP2
d. D1 and D2 Proteins
43. Following is not true for Agrobacterium infection of plant?
a. Vir A and G binds to acetosyringone
b. Vir D1/2 is responsible for single stranded cut in T-DNA
c. Vir B forms bridge between bacterium and plant cell during infection
d. Vir F and VIF coats single stranded T-DNA during passage from bacterium to nucleus of plant cell
44. The following is not a mechanism for removing pollutant from soil using phytoremediation?
a. Phytodegradation
b. Phytoextraction
c. Phytomining
d. Chelating pollutant by secretion of chemicals by plants
45. Which of the following is suitable for cloning 140 kb eukaryotic DNA fragments for constructing genomic library?
a. Phage
b. Plasmid
c. BAC
d. YAC
46. The use of biotinylated antiobody in ELISA?
a. increase specificity but compromises sensitivity
b. decreases both specificity and sensitivity
c. increase sensitivity without compromising specificity
d. cannot be used after transfer of protein on nitrocellulose sheet
47. Secondary sewage treatment involves
a. Sedimentation of organic wastes
b. Killing of pathogens by chlorination and opsionization
c. Use of trickling filters
d. Filtration
48. Which of the following pair are responsible for site specific recombination?
a. DNA polymerase III and ligase
b. DNA polymerase I and ligase
c. DNA polymerase II and ligase
d. Restriction endonuclease and ligase
49. If we want to test toxic effect of drug on liver then which would be suitable choice?
a. Liver cell line
b. Intact liver
c. Kupffer cells
d. Mixture of kupffer cells and liver cells
50. If ‘r’ denotes correlation coefficient and ‘m’ denotes slope of regression, then changing both X and Y axis will
a. change ‘r’ only keeping ‘m’ constant
b. keeps both ‘r’ and ‘m’ constant
c. change ‘m’ only keeping ‘r’ constant
d. changes both ‘r’ and ‘m’
51. As the plants are adapted for many photoreceptors for different wavelengths, which is true?
a. phytochrome A perceives red light
b. phytochrome C perceives far red light
c. phytochrome and cryptochrome perceives blue light
d. phytochrome B predominantly perceives far red light
52. Pholem Loading in plants is characterized by
a. movement of triose phosphate from chloroplast to cytosol
b. movement of sugar from source to sink in sieve element
c. mass flow of phloem sap to different parts of plants
d. transport of sugar from photosynthetic bundle sheath cell to companion cell
53. During pregnancy, the correct reason for initiating maternal behavior in females?
a. high level of estrogen and progesterone in blood
b. changes in uterine lining
c. high prolactin level in blood
d. sight of male
54. Sympathetic system increase heart rate by regulating
a. L type Ca2+ channel.
b. Na+ channel
c. T type Ca2+ channel
d. Cl- channel
55. One person suffering diabetes takes regularly 1 ml of insulin at 9 AM. One day he took 1.5 ml of insulin at scheduled time considering that he will go to party at 11 AM. But that day, he missed breakfast but took sufficient lunch in party. Which of the following scenario would be most suitable?
a. he will be hyperglycemic before lunch
b. he will be hypoglycemic after lunch
c. he will be hypoglycemic before lunch
d. Blood glucose level will remain in control before and after lunch
56. A tRNA gene is mutated at anticodon region to recognize stop codon and allow translation beyond pre mature stop codon in mRNA transcribed from mutated protein coding gene, such that functional protein is produced. Such a phenomenon is termed as
a. Reverse mutation
b. Neutral mutation
c. Nonsense suppressive mutation
d. Point mutation
57. A change on one locus to another locus of the same gene results in mutation. The two copies of mutated same gene termed as
a. complementation group
b. linkage group
c. duplicate genes
d. allele
58. A male mouse always produces female puff on mating. The reason is
a. defect in spermatogenesis
b. All sperms germ cells have X chromosomes
c. Activation of lethal gene associated with Y chromosome
d. Activation of lethal gene associated with X-chromosome
59. Two plants species having cob length of 9 cm and 3 cm were crossed. Assume trait for cob length is polygenic and additive property, what would be the cob length of progenies?
a. 3 cm
b. 6 cm
c. 9 cm
d. 12 cm
60. How many gametes would be formed from genotype AaBBccDdEe?
a. 8
b. 16
c. 32
d. 64
61. The correct explanation for paraphyltetic group?
a. contains unrelated organisms
b. includes recent ancestors
c. includes all common ancestors
d. includes all representatives but ancestors are not included
62. Which of the following microorganism extensively utilized in organic farming?
a. Rhyzopus
b. Trichorderma viride
c. Mucor
d. Fusarium
63. NOT an adaptation to xerophytic conditions in plants?
a. Sunken stomata
b. Sparse stomata
c. Lenticular tissues
d. Sclerenchymatous tissues
64. If the milk is left open in vessel, at first, lactose is fermented by bacteria producing acid. Later there is proteolytic degradation activity which increases pH and finally left over fat is degraded by another type of bacteria. This is an example of
a. Competition
b. Microevolution
c. Ecological succession
d. Antagonism
65. Which amongst the following has the highest per molecule green house effect?
a. CO2
b. CH4
c. NOx
d. CFCs
66. According to Hardy-Weinberg equilibrium, the allele frequency of gene pool will not change when
a. There is microevolution
b. There is migration
c. There is genetic drift
d. There is no evolution
67. Consider the following events in history of life?
I. prokaryotic cell
II. eukaryotic cell
III. natural selection
IV. organic macromolecules
V. formation of replicating molecule
Which of the following is correct sequence?
a. d→e→I→c→II
b. IV→V→I→II→III
c. IV→V→III→I→II
d. V→III→I→II→IV
68. During inter sexual selection the development of certain traits is seen only in males only, due to
a. Males experience lesser energy expenditure through maintenance of weapons, such as horns and antlers, then do females.
b. Male reproductive success is limited by access to forage more than female reproductive success is by access to forage
c. Female has very high reproductive and breeding cost as well as investment in parental care
d. Female reproductive success is more limited by access to males than male reproductive success is access to females.
69. The best technique to identify the Mycoplasma infection in animal cell line?
a. ELISA
b. PCR
c. Southern Hybridization
d. Northern Hybridization
70. In drug delivery, the major disadvantage of using liposome is
a. It is phagocytosised by neutrophils
b. It intercalates in plasma membrane
c. It is unstable and has small shelf life
d. Drug entrapment efficiency is very low
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